Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
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چکیده
منابع مشابه
Interleukin-1 a, Interleukin-1/?, and Tumor Necrosis Factor Gene Expression in Endotoxin-Induced Uveitis
Results. Little expression of IL-la, IL-1/3, and TNF genes was observed in normal ICB. IL-la gene expression began to increase (about 10-fold greater than that of the control) as early as 1 hour after the LPS treatment, reached a peak (about 100-fold) at 3 to 6 hours. A second peak (60-fold) was observed at 24 hours, and the expression returned to near basal levels (3-fold) at 48 hours. Express...
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Ledeboer, Annemarie, Rob Binnekade, John J. P. Brevé, John G. J. M. Bol, Fred J. H. Tilders, and AnneMarie Van Dam. Site-specific modulation of LPS-induced fever and interleukin-1 expression in rats by interleukin-10. Am J Physiol Regulatory Integrative Comp Physiol 282: R1762–R1772, 2002. First published February 7, 2002; 10.1152/ajpregu.00766.2001.—Bacterial lipopolysaccharide (LPS) induces f...
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The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a variety of genes and the synthesis of several proteins that, in turn, induce acute and chronic inflammatory changes. IL-1 is also the prototypic "alarm" cytokine in that it brings about increases in a variety o...
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Signaling through the IL-1-receptor type 1 (IL-1R1), IL-1 is required for initiation and maintenance of diverse activities of the immune system. A second receptor, IL-1R2, blocks IL-1 signal transduction. We studied expression of IL-1beta, IL-1R1, and IL-1R2 in 17 Hodgkin lymphomas (HL) by in situ hybridization (ISH). IL-1beta expressing cells, morphologically consistent with endothelial cells ...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2011
ISSN: 1742-2094
DOI: 10.1186/1742-2094-8-175